羟丁酸钠对氯胺酮药效学的影响

Effects of sodium oxybate on pharmacodynamics of ketamine in animals

用清醒动物研究了羟丁酸钠与氯胺酮的相互作用。羟丁酸钠可增大小鼠静注氯胺酮的LD_和氯胺酮引起的小鼠入睡率,延长小鼠睡眠时间,减少躁动,并与氯胺酮的镇痛作用协同。羟丁酸钠对氯胺酮的呼吸、循环效应无明显影响。结果提示,羟丁酸钠可增强氯胺酮的麻醉作用,减轻其不良反应,与氯胺酮组成复合麻醉是合理的。

The interaction between sodium oxybate and ketamine were studied in conscious animals. Sodium oxybate increased the LD_(50) of ketamine, increased the incidence of sleep caused by ke tamine and prolonged the sleep duration and potentiated analgesic action of ketamine. Sodium Oxybate didn't effect the respiratory and circulatory function in rabbits. The results showed sodium oxybate po tentiated the anesthetic action of ketamine and reduced the side effect of ketamine. So It is suggested that sodium oxybate has the anesthetic synergism with ketamine in animals.