全麻手术患者异丙酚的药代动力学

Clinical pharmacokinetics of intravenous propofol

为探讨异丙酚的药代动力学指标,选择8例全麻成人择期手术患者,单次静脉注射异丙酚2mg/kg后,用高效液相色谱法测定血浆中异丙酚浓度,采用PKBP-NI程序进行数据处理。结果表明药代动力学符合三室开放模型,回归分析取得药代动力学参数。T_(1/2α)=0.011h,T_(1/2β)=0.193h,T_(1/2β)=2.630h,Vd=0.175L/kg,K_(10)=10.40h,K_(31)=0.660h,表明异丙酚消除快,分布广,且受到三室缓慢平衡的影响,不仅可作为麻醉诱导,也适于连续静脉滴注维持麻醉。

In order to investigate the pharmacokinetics of propofol, 8 adult patients, ASA grade Ⅰ-Ⅱ, scheduled for elective operation under general anesthesia,served as the subjects. After the injection bolus of propofol 2mg·kg~_(-1) was given, the venous blood samples were taken at various times to measure the plasma concentrations of propofol by high performance liquid chromatography. The data were analysed using PKBP-NI program. The results showed that the disposition of propofol was mathematically described by three compartment open motile, the distribution was rapid and extensive with slow balance among three compartments,and the eliminative duration was short. It is indicated that propofol is applicable for both induction and maintenance of anesthesia.