实验甲低功大鼠肝、肾线粒体中磷酸甘油脱氢酶活性测定

ACTIVITY MEASURMENT OF MITOCHONDRIAL -GLYCEROPHOSPHATE DEHYDROGENASE IN LIVER AND KIDNEY OF HYPOTHYROID RATS

给实验大鼠饮含０．５％ＮａＣｌＯ_４的自来水，造成甲状腺功能低下，测定甲低功状态下肝、肾组织中线粒体α－磷酸甘油脱氢酶（α－ＧＰＤ）的活性。结果表明，实验组肝、肾α－ＧＰＤ活性明显低于对照组，Ｐ＜０．０１。血清Ｔ_３、Ｔ_４与肝脏α－ＧＰＤ活性进行相关检验，提示血清Ｔ_３、Ｔ_４与肝脏α－ＧＰＤ之间有明显的相关。

The purpose of this study was to determine mitochondrial-glycerophosphate dehydrogenase(α-GPD)activity in liver and kidney of hypothyroid rats.The experimental hypothyoid rats wene induced with 0.5%NaClo_4 put in their drinking water.The results showed that the(α-GPD activity of liver and kidney decreased significantly in the contiol group(P<0.01).changes of(α-GPD activity directly related to concentration of T_3 and T_4 in serum.Based on the α-GPD and T_3 and T_4 the organs that is sensitive to thyroid hormone can be found out.