大肠埃希菌对环丙沙星耐药率及其主要影响因素分析

Ciprofloxacin-resistant Rate of Escherichia coli and Its Main Impact Factors

目的调查大肠埃希菌（ECO）临床分离株对环丙沙星耐药率现状，分析其主要影响因素，指导ECO感染的经验性治疗。方法收集湖北省细菌耐药性监测网上的有关资料，用WHONET5．2软件统计耐药率，用SAS软件进行一元和多元非条件Logistic回归分析。结果ECO对环丙沙星耐药率呈增高趋势，并因实验室、患者来源、患者年龄和性别而异，差异具有统计学意义（P〈0．01）；年龄是影响耐药率的主要因素（STB=0．1384，OR=1.012，95％CI 1．0091．015）。结论常规剂量的氟喹诺酮类抗菌药物不宜单独用于经验性治疗ECO感染，特别是对泌尿道感染的中老年男性患者。

OBJECTIVE To retrospectively investigate the ciprofloxacin-resistance rate of Escherichia coll （ECO） and its main impact factors,and then guide empiric therapy for its infection. METHODS We looked up relative data in Hubei Network for Surveillance of Bacterial Antimicrobial Resistance. WHONET 5.2 Software was used to analyze resistance rates, and SAS software to perform univariate and multivariate Logistic regression assay. RESULTS Ciprofloxacin-resistance rate of ECO was and is on the rising, meanwhile, its resistance rates were different for laboratory, patient origin, age group, gender and so on, and the differences were all very significant （P〈0.01）. Age was a major impact factor for ciprofloxacin-resistance（STB=0. 1384, OR= 1. 012, 95% CI 1. 009-1. 015）. CONCLUSIONS Routine dosage of fluoroquinolones is not fit for empiric monotherapy for ECO infection,especially for middle-aged and old male patients with urinary tract infection.