儿童尿路感染病原菌分布及耐药性调查

Urinary Tract Infection for Children:Pathogen Distribution and Drug-resistance Investigation

目的了解武汉地区儿童尿路感染的病原菌分布及耐药现状,为临床提供诊断与治疗依据。方法分析2002年7月-2005年12月405例尿路感染患儿尿培养阳性结果,药敏试验采用K-B法。结果405株病原菌中大肠埃希菌占首位,为36.7%;其次为肠球菌属,占29.4%;405株病原菌均显示了较高的耐药性,仅亚胺培南、阿米卡星和呋喃妥因对大肠埃希菌和肺炎克雷伯菌、糖肽类和高浓度链霉素及呋喃妥因对肠球菌属保持了较好的抗菌活性。结论应采取有效措施,合理使用抗菌药物,遏制儿童尿路感染耐药菌的产生与流行。

OBJECTIVE Investigating the distribution and drug-resistance of pathogenic bacteria in urinary tract infecion for children in Wuhan region to provide the evidence of diagnoses and treatment for clinician. METHODS The positive results of urine culture of 405 children with urinary tract infections from Jul 2002 to Dec 2005 were analyzed. All of the isolates were tested by Kirby-Bauer susceptibility method. RESULTS Among 405 pathogens, the majority was Escherichia coli which occupied 36.7% ; then Enterococcus accounted for 29. 4%. Totally 405 pathogens all showed the higher drug resistance,while antibacterial antivities of imipenem,amikacin and furantoin to E. coli and Klebsiella pneumoniae and of glycopeptides, high concentration of streptomycin and furantoin to Enterococcus were preserved well. CONCLUSIONS The effective measurements and reasonable use of antibiotics should be taken to hold back the occurrence and prevalence of urinary tract infecion for children.