气相-质谱联用法检测收缴滥用物质检测条件的优化

Method Optimization of the Determination of the Components and Impurities of Illicit Drugs by GC-MS

目的:同一收缴滥用物质,用不同的气相-质谱(GC-MS)联用条件检测,优化检测滥用物质的条件。方法:通过选择不同的进样口温度、载气流速、炉温起始温度、程序升温速率、炉温终末温度及保持时间,检测同一收缴滥用物质,研究不同检测条件对收缴滥用物质检测结果的影响,优化检测条件。结果:不同的检测条件对被检测滥用物质的保留时间、峰形、峰面积有一定的影响。结论:气相-质谱联用法检测收缴滥用物质的优化条件为:检测器为质谱检测器,温度280℃;扫描方式为Scan;进样口温度为250℃～280℃;载气流速为0.8ml·min-1;炉温为程序升温,起始温度为80℃～100℃,程序升温速率5℃·min-1～10℃·min-1,炉温终末温度为300℃,保持时间为10min～15min。

Objective： To optimize the methods of the determination of the components and impurities of illicit drugs by GC-MS. Methods： Determination of the components and impurities of illicit drugs by GC-MS, selecting different injector temperature, carrier gas flow rate, initial temperature, temperature programming rate, final temperature and holding period, to investigate the influence of these facts on the results of determination. Results： The different methods of the determination influence retention time, peak shape and peak area of the components and impurities of illicit drugs especially. Conclusion： Optimal methods of the determination of the components and impurities of illicit drugs by GC-MS： detector temperature 280℃, injector temperature 250℃-280℃, carrier gas flow rate 0.8 ml· min^-1, initial temperature 80 ℃- 100 ℃, temperature programming rate 5 ℃ · min^-1-10 ℃ · min^-1, final temperature 300℃ and holding period 10 min-15 min.