念珠菌型小鼠乳房炎组织损伤程度与C_(3c)补体激活水平相关性的研究
被引量:1
摘要
本试验将36只父母代分娩后4~5d的母鼠通过人工乳腺注射念珠菌感染分别构建正常小鼠、裸鼠和免疫缺陷型小鼠乳房炎模型,并分别建立未用药组和对照组(用药组)(n=6),通过对血清中C3c水平的检测以及乳腺病理组织切片的观察,结果表明乳腺型念珠菌感染可以激活补体旁路,且C3c水平与感染后炎症的程度呈正相关,各处理组差异显著;外源性抗真菌药物的治疗可降低C3c水平,与C3c水平呈负相关。
出处
《中国畜牧兽医》
CAS
2007年第1期92-93,共2页
China Animal Husbandry & Veterinary Medicine
参考文献11
-
1Balish E,Jensen J,Warner T,et al.Mucosal and disseminated candidiasis in gnotobiotic SCID mice.J Med Vet Mycol,1993,31:143~154.
-
2Cooper N R,Nemerow G R.Complement and infectious agents:a tale of disguise and deception.Complement In£amm,1989,6:249~258.
-
3Fearon D T.The complement system and adaptive immunity.Semin Immun,1998,10:355~361.
-
4Fidel P L,Sobel J D.The role of cell mediated immunity in candidiasis.Trends Microbiol,1994,2:202~206.
-
5Fidel P L J,Cutright J L,Sobel J D.Eiects of systemic cell-mediated immunity on vaginal candidiasis in mice resistant and susceptible to Candida albicans infections.Infect Immun,1995,63:4191~4194.
-
6Guhad F A,Jensen H E,Aabaek B,et al.A murine model for the study of mycotic mastitis.J Comp Pathol,1995,113:315~325.
-
7Kozel T R.Activation of the complement system by pathogenic fungi.Clin Microbiol Rev,1996,9:34~46.
-
8Mahanty S,Green¢eld R A,Joyce W A,et al.Inoculation candidiasis in a murine model of severe combined immunode-ciency syndrome.Infect Immun,1998,56:3162~3166.
-
9Pearsall N N,Adams B L,Bunni R.Immunologic responses to Candida albicans.Ⅲ.Eiects of passive transfer of lymphoid cells or serum on murine candidiasis.J Immunol,1978,120:1176~1180.
-
10Teisner B,et al.Circulating C3,C4,and C3 split-products during normal pregnancy.Am J Reprod Immunol,1983,2:309~311.
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-
1宋蓉,陈月,吕凤林.C5L2不再是孤儿受体——进展与展望[J].免疫学杂志,2007,23(2):229-232. 被引量:2
-
2陈月,吕凤林.补体C5a新型抑制剂研究进展[J].中国免疫学杂志,2007,23(2):180-184. 被引量:6
-
3Ager R, Fonseca M, Chu S, et al. Decreases in Alzheimer's dis- ease like pathology associated with C5aR inhibition correlate with improved performance in a passive avoidance task[J]. Molecular Immunology, 2008, 45(16): 4109.
-
4Arumugam T V, Shiels I A, Woodruff T M, et al. Protective effect of a new C5a receptor antagonist against isehemia-reperfu- sion injury in the rat small intestine[J]. Surgical Research, 2002, 103(2): 260-267.
-
5Arumugam T V, Woodruff T M, Shelli Z, et al. Protective effect of a human C5a receptor antagonist against hepatic ischae- mia-reperfusion injury in rats[J]. Hepatology, 2004, 40 (6) : 934-941.
-
6BeckK D, Nguyen H X, Galvan M D, et al. Quantitative analy- sis of cellular inflammation after traumatic spinal cord injury: Evidence for amultiphasic inflammatory response in the acute to chronic environment[J]. Brain, 2010, 133(2): 433-447.
-
7Blagg J, Mowbray C, Pryde D C, et al. Small, non-peptide C5a receptor antagonists: Part l[J]. Bioorganic and Medicinal Chem- istry Letters, 2008, 18(20): 5601-5604.
-
8Boor P, Konieczny A, Villa L, et al. Complement C5 mediates experimental tubulointerstitial fibrosis[J]. American Society of Nephrology, 2007, 18(5) : 1508-1515.
-
9Brodbeck R M, Cortright D N, Kieltyka A P, et al. Identifica- tion and characterization of NDT 9513727EN, N-bis(1, 3-benzo- dioxol-5-ylmethyl )-l-butyl-2, 4-diphenyl-lH-imidazole-5-meth- anamine3, a novel, orally bioavailable C5a receptor inverse ago- nist[J]. Pharmacology and Experimental Therapeutics, 2008, 327(3) : 898-909.
-
10Bunschoten A, Ippel J H, Kruijtzer J A, et al. A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus : Towards the development of novel anti-inflammatory compounds [J]. Amino Acids, 2011, 40(2): 731-740.
-
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-
2潘荣华.救命的智慧[J].新智慧,2009(3):45-45.
-
3王德照,仇波,夏康平,杨淑琴,关淑娟,闫常平,薛克云,郭井利.肉仔鸡腺胃型传染性支气管炎与念珠菌病混合感染的诊治[J].中国家禽,2000,22(12):25-26.
-
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-
5图布丹扎布,甘政权,曹跃,韩继平,刘成旺.鸡念珠菌感染的调查[J].中国人兽共患病杂志,1996,12(3):55-56. 被引量:2
-
6丁卫华,刘平,陈建清.种鸽口粘膜念珠菌感染的诊治[J].中国家禽,2001,23(18):33-33.
-
7黄学祥,冯生智,冯立红.雏珍珠鸡念珠菌感染的诊治报告[J].宁夏农林科技,2002,43(2):60-60.
-
8戴锦龙,曹艳杰,李和鸣,韦英益,张丽华,何怡宁,谢智文,韦天超,韦平,磨美兰.鸡传染性支气管炎病毒MM41株感染雏鸡的组织病理学研究[J].中国家禽,2015,37(23):16-21. 被引量:1
-
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-
10刘锦妮.孔雀念珠菌感染的中药诊治[J].中兽医医药杂志,2013,32(3):65-66. 被引量:2