摘要
目的探讨WWOX(WW dom ain containing oxidoreductase)mRNA在卵巢上皮性癌组织中的表达及其临床意义。方法采用RT-PCR技术检测39例卵巢上皮性癌、17例卵巢交界性上皮性肿瘤、29例卵巢良性上皮性肿瘤及31例正常卵巢组织中WWOX mRNA的表达,并分析其与各临床病理指标的相关性。结果WWOX mRNA在卵巢上皮性癌及卵巢交界性上皮性肿瘤组织中的阳性表达率(分别为20.5%、41.2%)及表达水平(分别为0.29±0.12、0.55±0.09)均显著低于卵巢良性上皮性肿瘤及正常卵巢组织(分别为68.9%、70.9%)和(0.85±0.13、0.86±0.16)(P均<0.05);且WWOX mRNA在卵巢上皮性癌组织中的阳性表达率和表达水平均与手术病理分期和淋巴结转移有明显的相关性(P<0.05)。结论WWOX mRNA在卵巢上皮性癌组织中呈低表达,其不同程度的表达缺失与卵巢上皮性肿瘤的发生发展有关。
Objective To study the expression and significance of WWOX mRNA in epithelial ovarian cancer. Method The expression of WWOX mRNA evaluated by RT - PCR and its clinical significance were studied in 39 patients with epithelial ovarian cancer, 17 borderline epithelial ovarian tumor, 29 epithelial benign tumor and 31 normal. Results The positivity and relative content of WWOX mRNA were 20.5% and 0. 29 ± 0. 12 respectively in patients with epithelial ovai＇ian cancer, lower than those in borderline epithelial ovarian tumors （41.2% and 0. 55 ±0.09） , epithelial benign tumor （69 % and 0. 85 ±0. 13） and normal ovarian tissue （71% and 0. 86 ＋0. 16） （P 〈0.05 ）. The positivity and relative content of WWOX mRNA in patients with epithelial ovarian cancer were found to be correlated with the clini cal stage and lymph node metastasis （P 〈 0. 05 ）. Concusion WWOX mRNA is lowly expressed in epithelial ovarian cancer; its expression level is related to the incidence and development of epithelial ovarian tumor.
出处
《徐州医学院学报》
CAS
2007年第2期126-128,共3页
Acta Academiae Medicinae Xuzhou
