莫昔沙星序贯治疗社区获得性肺炎

Sequential Moxifloxacin Administration in the Treatment of Community Acquired Pneumonia

目的观察莫昔沙星序贯治疗社区获得性肺炎(CAP)的安全性和临床疗效。方法94例CAP患者随机分为治疗组和对照组各47例。治疗组先给予莫昔沙星注射液400 mg,静脉滴注,qd,连用5 d后,改用莫昔沙星片400 mg,po,qd,共9 d;对照组先给予头孢呋辛钠1.5 g,iv,tid,连用5 d后改头孢呋辛酯片500 mg,po,bid,共9 d。两组全疗程均为14 d。结果治疗组与对照组的总有效率分别为93.6%和78.7%(P<0.05);细菌总清除率分别为91.3%和86.4%(P>0.05)。结论莫昔沙星序贯治疗CAP安全,有效,方便。

Objective To s ey the safety and clinical therapeutic effectiveness of sequential moxifloxacin administration in the treatment of community acquired pneumonia （CAP）. Methods Ninety-four cases of CAP were randomly divided into 2 equal groups： the treatment group and control group. Patients in the treatment group were given each 400 mg of moxifloxacin injection administered by intravenous instillation q.d. for 5 consecutive days , followed by 400 mg of moxifloxacin tablets PO,q. d. for 9 consecutive days. Patients in the control group were given each 1. 5g of cefuroxime sodium injection administered by intravenous injection, t, i. d. for 5 consecutive days, followed by 500 mg of cefuroxime sodium tablets PO, b. i.d. for 9 consecutive days. The full course of treatment in both groups lasted 14 days. Results The overall effective rates in patients treated with moxifloxacin and cefuroxiume sodium were 93.6% and 78, 7%, respectively （ P 〈 0.05 ）. The total bacteria elimination rates in patients treated with moxifloxacin and cefuroxiume sodium were 91.3% amd 86.4%, respectively （ P 〉 0. 05）. Conclusion The sequential moxifloxacin medication is safe, effective and handy in the treatment of patients with community acquired pneumonia.