微波辐射下氧化N-烷基酰胺合成二酰亚胺(英文)

Synthesis of Imide by Oxidation of N-Alkyl Amides under Microwave Irradiation

二酰亚胺是一个很有用的官能团,它广泛存在于天然产物和有药物活性的分子中.通过微波辐射条件合成它吸引了很多化学家的注意.极性反应物可以吸收微波辐射,化学家将微波应用于一些化学反应中.N-烷基酰胺(NH邻位有一个亚甲基CH2)和N上没有取代的内酰胺可以被过氧化物和过渡金属盐氧化成二酰亚胺.报道了在乙酸乙酯中过氧叔丁醇和乙酰丙酮锰(III)在微波条件(90W,5min)下,酰胺迅速、高选择性地、高产率地转变为二酰亚胺的方法.

Imide group is an interesting functionality, due to its wide presence in the natural products and in the pharmacologically active compounds. This has attracted chemists＇ attention as a target to be prepared by microwave irradiation. Since polar reactants can absorb the microwave irradiation, thus chemists can utilize the microwave oven for some organic reactions. N-Alkyl amides （with methylene CH2 group adjacent to NH function of amide bond） and lactams, which need not be N-substituted, can be converted to imides by oxidation with a hydroperoxide and transition metal salts. It was reported that a rapid, selective and good yield conversion of the amides to imides by using t-buthyl hydroperoxide （t-BuOOH） and manganese（Ⅲ） acetylacetonate [Mn（acac）3] in ethyl acetate under microwave irradiation （90 W, 5 min）.