常温充氧晶体/血心停搏液持续灌注对心肌能量代谢、水及电解质的影响

Myocardial energy-water and electrolyte balance during continuous infusion with normothermic oxygenated crystalloid solution or blood cardioplegia

本研究采用离体兔心模型，观察常温充氧晶体心停搏液（A组，n＝8）和常温氧合血心停搏液·（B组，n＝8）持续灌注两种方法对心肌能量代谢、水及电解质的影响，借以评价此两种方法对心肌的保护效果。结果发现两组心肌腺苷酸含量，能荷（EC）、水含量及电解质（Na＋、K＋、Ca＋＋、Mg＋＋）在停跳前、停跳10min、45min、复跳10min无明显差别，且两组同期比较上述指标亦无统计学差异。提示：常温充氧晶体心停搏液与常温氧含血心停搏液对缺血期心肌均具有良好的保护效果，两组无明显差别．

Alterations in myocardial electolyte balance and energy metabolism were investigated between continuous coropary infution with normothermic oxygenated crystalloid cardioplegia (group A, n=8) and with normothermic oxygenated blood cardioplegia (group B, n=8) in isolated rabbit heart. The results showed that no significant difference was found in myocardial adenine nucleotide contents, energy charge, water contents, and Na+, K+, CaH, Mg++ at prearrest, postarrest 10 min,45min and restroke 10 min in or between group A and group B. It is suggested that continuous coronary infusion with normothermic oxygenated crystalloid solution or normothermic oxygenated blood cardioplegia may has a beneficial effect on the pro-tection of ischemic myocardium and no difference was found between them.