尼群地平（98例）与阿替洛尔（92例）治疗老年高血压病的比较

Nitrendipine(98 patients) vs atenolol (92 patients) in treating hypertension in aged

目的：比较尼群地平与阿替洛尔治疗老年高血压病的疗效。方法：老年高血压病人９８例（男性７９例，女性１９例；年龄６４±ｓ９ａ）给予尼群地平１０ｍｇ，ｐｏ，ｔｉｄ，共服１ｍｏ。对照组为同样的病人９２例（男性７７例，女性１５例；年龄６０±９ａ）给予阿替洛尔２５ｍｇ，ｐｏ，ｔｉｄ，共服１ｍｏ。结果：尼群地平组显效６８％，有效２４％，总有效率９２％；阿替洛尔组显效４１％，有效２６％，，总有效率６７％；２组总有效率差异非常显著（Ｐ＜０．０１）。结论：尼群地平治疗老年高血压病优于阿替洛尔。

AIM :To compare the efficaciy of nitrendipine with atenolol in old patients with hypertension. METHODS:Nitrendipine was given orally to 98 patients(M 79,F19,age 64 ± s9a) ,10mg,tid,for 1 mo. In the controlled group,atenolol was given orally to 92 patients(M 77,F 15,age 60 ± 9 a),25 mg,tid,for 1 mo. RESULTS:In the nitrendipine group,theexcellent response rate was 68 %,the effective rate was 24 %,and the total response rate was 92% . In the atenolol group,the excellent response rate was 41%,the effective rate was 26%,and the total response rate was 67%. There were significant differences (P<0.01) between the 2groups in the total response rates. CONCLUSION :In the treatment of hypertension in elderly patients nitrendipine is superior to atenolol.