异帕米星治疗下呼吸道感染

Isepamicin in treating lower respiratory tract infections

目的：观察异帕米星对下呼吸道感染的疗效。方法：下呼吸道感染４２例（男性３２例，女性１０例；年龄５６±ｓ１３ａ），以异帕米星注射液４００ｍｇ／ｄ，静脉滴注，疗程８．７±２．３ｄ．结果：临床有效率８１％（３４／４２），细菌清除率６９％（２４／３５）。临床分离的６１株革兰阴性（Ｇ－）杆菌作体外药敏测定显示对异帕米星的耐药率为３０％，明显低于庆大霉素的耐药率（４８％）。结论；异帕米星治疗下呼吸道感染疗效满意。

AIM:To observe the therapeutic effect of isepamicin(Ise in treating lower respiratory tract infections. METHODS:Forty-two patients with lower respiratory tract infections (M32,F10;age 56±s 13 a) received Ise 400 mg/div drop for 8.7±2.3d.RESULTS:The clinical response rate was 81%(34/42) and bacteria clearance rate 69%(24/35). One patient had drug eruption,2patients appeared transitionally elevated BUN. The MIC of Ise against clinical isolates of 61 G-bacillus showed the resistant rate was 30%,very lower than that of gentamicin(48%).CONCLUSION:In treating lower respiratory tract infections with bacteria,Ise would be satisfactory.