生大黄粉灌肠在重症急性胰腺炎治疗中的临床价值

The Curative Effect of Chinese Medicine Rhubarb by Enema in Severe Acute Pancreatitis

目的探讨善宁联合大黄对急性重症胰腺炎的治疗效果。方法将40例急性重症胰腺炎患者随机分为二组:治疗组20例,为善宁联合大黄治疗组;对照组20例,为善宁治疗组。观察患者治疗前后血清炎症因子 TNFα、IL-1b 水平、血淀粉酶、血脂肪酶、血白细胞计数及腹部症状缓解情况。结果治疗组血清 TNFα、IL-1b、血淀粉酶、血脂肪酶及血白细胞计数下降水平及腹部症状缓解情况明显好于对照组。结论中药大黄能明显促进胃肠道功能恢复,减少肠道细菌移位,减轻急性炎症反应综合征,减轻胰腺损害,促进胰腺修复,提高疗效,缩短疗程。联合应用善宁和大黄治疗急性重症胰腺炎可提高治疗效果,缩短住院天数。

Objective To explore the preventive and therapeutic effect of rhubarb and sandostatin on severe acut pancreatitis （SAP）. Methods 40 cases of SAP were randomly divided into 2 groups. The control group（ n =20） and the treatment group （ n =20）. Routine treatments were given in beth groups, the Chinese medicine rhubarb was used in treatment group. All patients were hospitalized to observe and compare between two groups. Blood samples were taken seven days after using injection of testing agents for biochemical test which included of TNFα,IL-1b,serum amylase,lipase,leucocyte and the time of abdominal distension releaving. Results Every record of the treatment group was better than control group. Conclusion The chinese medicine rhubarb showed their protective effects on gut barrier function by alleviating the damage the intestinal mucesa following acute pancreatitis. As a result , the chance of bacterial translocation and enterogenic infection declined. These preparation might raise the treatment effects, as a well , shorten the course of treatment .