一氧化碳中毒迟发性脑病58例临床研究

Clinical Study of Delayed Encephalopathy After Acute Carbon Monoxide Poisoning and Effect of Hyperbaric Oxygen Treatment(Reported of 58 Cases)

目的探讨一氧化碳(CO)中毒迟发脑病的临床特点、发病相关因素及高压氧治疗的作用。方法回顾性分析58例确诊的 CO 中毒迟发脑病患者的临床资料。结果 58例中,发生在低浓度、长时间 CO 环境者占81.0%,昏迷4 h 以上者占67.2%,年龄40岁以上者占70.7%,未正规行药物及高压氧综合治疗者占93.1%。坚持高压氧综合治疗后痊愈及生活基本自理者占84.2%,影像学表现恢复率为87.9%。结论 CO 中毒迟发脑病的发生与中毒原因、病情轻重、年龄、合理治疗与否有密切关系,高压氧对本病的预防和治疗具有重要的作用。

Objective To explore the clinical characterics and pathogenesis of delayed encephalopathy after acute carbon monoxide poisoning （DEACMP） and to discuss the effect of hyperbaric oxgen treatment Methods A review analysis of 58 DEACMP patients including the clinical data such as age range,poisoning degree poisoning appearance etc were made. Results 81% of the 58 DEACMP patients were under low concentration but long -term contact with carbon monoxide,67. 2% had in a coma state for over 4 hours,70. 7% were over 40 years of age,93. 1% did not treat with normal drug and hyperbaric oxygen while 84. 2% recuperated health under hyperbaric oxygen treatment whose recovery rate of normal behavior was 87. 9%. Conclusion DEACMP is closely associated with poisoning appearance,poisoning degree,age and reasonable treatment Hyperbaric oxygen has a great influence on DEACMP prevention and treatment