大肠癌患者VEGF、nm23及COX-2表达的临床意义

Clinical Significance of Expression of Vascular Endothelial Growth Factor、nm23 and COX-2 in Carcinoma of Large Intestine

目的:探讨人大肠癌组织中VEGF、nm23和COX-2表达与临床意义。方法:应用免疫组化方法,检测60例大肠癌组织中VEGF、nm23和COX-2表达,分析其与大肠癌患者预后的关系。结果:VEGF、COX-2表达依大肠癌临床分期、、期顺序而上升(P<0.05),同时与大肠癌有无淋巴结转移密切相关(P<0.05)。VEGF、COX-2阴性表达患者3、5a生存率高于阳性表达组(P<0.05)。VEGF、COX-2阴性表达组nm23表达高于阳性表达组(P<0.05)。结论:VEGF、nm23、COX-2可作为估计大肠癌预后的指标。

Objective：To explore the expression of vascular endothelial growth factor （VEGF）,nm23 and COX-2 and their clinical significance in human carcinoma of large intestine. Methods ：The expressions of VEGF,nm23 and COX- 2 in 60 samples of human carcinoma of large intestine were detected by the immunohistochemical staining, and the results were related to prognosis. Results ：The expressions of VEGF,COX-2 ascended significantly according to the following order：human carcinoma of large intestine of clinical stage Ⅰ、Ⅱ、Ⅲ （P〈0.05）. Meantime, the expressions of VEGF, COX-2 were prominently determined by positive or negative metastatic node （P〈0. 05）. The 3-year, 5-year survival rate were significantly higher in patients with negative VEGF,COX-2 expression than those with positive expression（P〈 0. 05）. The nm23 expression of the VEGF,COX-2 negative group was significantly higher than those of positive group （P〈0. 05）. Conclasion：VEGF,nm23 and COX-2 may be a valuable marker in predicting prognosis in human carcinoma of large intestine.