芪苈强心胶囊对兔实验性慢性心力衰竭心室重构的保护作用被引量：54

Protective effects of Qiliqiangxin capsule in rabbit heart ventricle reconstitution of chronic heart failure

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摘要目的观察芪苈强心胶囊对兔实验性慢性心力衰竭心室重构的保护作用。方法采用腹主动脉半结扎术所致兔慢性心力衰竭模型。65只兔随机分为假手术组、模型对照组、地高辛组和芪苈强心高、中、低剂量组。观察血流动力学、标志心室重构的室壁厚度及心脏指数及肾素—血管紧张素—醛固酮系统(RASS)相关生化指标的变化。结果芪苈强心胶囊可有效降低血压、左室压、左室末期舒张压、T波,改善室壁厚度和心脏指数,降低血清血管紧张素II及醛固酮水平,与模型组比较均有显著性差异(P<0.05,P<0.01)。结论芪苈强心胶囊可改善慢性心力衰竭兔血流动力学的变化,对慢性心力衰竭引起的心室重构具有显著抑制作用,其机制可能与该药发挥抑制神经内分泌免疫系统RASS中An-gII、ALD的水平有关。 Objective To observe the protective effect of Qiliqiangxin capsule in rabbit heart ventricle reconstitution of chronic heart failure. Methods Using the method of giving rabbit abdomen aorta half ligations to build the chronic heart failure model to observe Qiliqiangxin capsule the effect to blood flow mechanics index, room wall thickness, heart exponent and heart ventricle reconstitution biochemistry index. Results Qiliqiangxin capsule could reduce effectively BP, LVSP, LVEDP, T wave, improve room wall thickness and heart exponent, reduce AngⅡ and ALT, all the paramenters ahd notable difference, composed to those of model group （ P 〈 0.05, P 〈 0.01 ）. Conclusion Qiliqiangxin capsule can improve the blood flow mechanics change of chronic heart failure rabbit, which has notable inhibitory action on heart ventricle reconstitution which originate from chronic heart failure. Inhibition of AngⅡ, ALT of immune nerve endocrine system may be a mechanism of Qiliqiangxin capsule.

作者魏聪贾振华吴以岭刘建勋

机构地区河北医科大学医药研究院中国中医科学院西苑医院

出处《疑难病杂志》 CAS 2007年第3期144-147,共4页 Chinese Journal of Difficult and Complicated Cases

关键词芪苈强心胶囊心力衰竭慢性心室重构保护作用兔 Qihqiangxin capsule Chronic heart failure Heart ventricle reconstitution Protection effect Rabbits

分类号 R285.5 [医药卫生—中药学]

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参考文献4

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