通心络对急性冠状动脉综合征患者血浆黏附分子的影响

The effect of Tongxinluo capsule on the plasma adhesion molecule in patients with acute coronary syndrome

目的探讨通心络胶囊对急性冠脉综合征(ACS)患者血浆黏附分子的影响。方法100例ACS患者随机分为常规治疗组和通心络治疗组(常规治疗+通心络胶囊),观察治疗前及第7、14d血浆C-反应蛋白(CRP)、可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)的变化。结果与治疗前相比,第7、14d通心络组血浆CRP、sICAM-1和sVCAM-1水平均有显著下降(P<0.05或P<0.01),而常规治疗组仅第14d有显著变化(P<0.05)。通心络组CRP、sICAM-1和sVCAM-1水平均显著低于常规治疗组(P<0.01)。结论通心络可能通过抑制可溶性细胞黏附分子、减少血管内膜的炎症反应等途径改善血管内皮功能,从而达到对血管内皮的保护作用。

Objective To investigate the effect of Tongxinluo on the plasma adhesion molecule in acute coronary syndrome （ACS） patients. Methods 100 patients with ACS were ranolomly divided into conventional therapy group and treatment group（conventional therapy ＋ Tongxinluo gelatin capsule） to observe the change of C-reactive protein（CRP）, soluble intercellular adhesion molecule-1 （sICAM-1） and soluble vascular cell adhesion molecule-1 （sVCAM-1） at first day,7th and 14th day. Results In treatment group, CRP, sICAM-1 and sVCAM-1 were significant decreased at 7th and 14th day（ P 〈0.05 or P 〈0.01）.There was significant decrease only at the 14th day （ P 〈 0.05）in conventional therapy group.Conclusion Tongxinluo capsule has proteetive effect on blood vessel endothehum.