碘油肺动脉治疗性栓塞的实验研究

Therapeutic Embolization of Pulmonary Artery with Lipiodol-An Experimental Study

为了解正常肺组织对碘油肺动脉栓塞的反应,在19只兔子耳缘静脉推注碘化油-阿霉素乳剂。定期处死,肺标本钼靶摄片示:注射后即刻碘油沉积在兔肺动脉小分支及肺组织,随着时间推移碘油沉积量逐渐减少,术后5月碘油完全清除。病理学检查示:术后半天内主要为肺组织弥漫性炎症改变伴残留肺泡代偿性过度通气,大量碘油沉积在肺组织内,术后一天起出现明显的组织细胞反应性增生,组织细胞浆内有大量碘油颗粒,术后3周至1月炎症吸收,碘油呈灶性沉积在肺组织内,术后2月肺组织结构恢复正常,术后5月磺油完全消失。实验表明:采用碘油乳剂进行肺动脉栓塞治疗是安全可行的。

Lipiodol-Duxurubincin emulsion was injected into pulmonary artery in 19 rabbits (0.5ml/kg) to investigate changes of pulmonary tissues after embolization of pulmonary artery with Lip iodol. Rabbits were killed and lungs were kept for soft tissue radiography and histological examination. Soft tissue radiographes revealed that Lipiodol accumulated in pulmonary tissues and small branches of pulmonary artery immediately after injection, then gradually reduced. Focal Lipiodol deposits were found in one month, and disap, peared in 5 months. Histologically, diffuse inflammatory changes of pulmonary tissues and hy perinflation of residual alveoli were found within 12 hours after injection Lipiodol depost in large amount was found in pulmonary tissues. Histocyte proliferation began from the first day with obvious reduction of Liplodol. Large amount of Lipiodol particles were found in cytoplasm of histocytes. Focal Lipiodol deposit was found within one month, and inflammation disappeared, The pulmonary tissues were normal in 2 months, and no Lipiodol were found in 5 months. The response of pulmonary tissues to pulmonary arterial embolization with Lipiodol emulsion is an inflammatory process. Lipiodol deposited in pulmonary tissues is cleared away by macrophage of histo cytes. And, it is safe to do therapeutic embolization of pulmonary artery with Lipiodol.