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XIAP与肿瘤化疗耐药关系的研究进展 被引量：1

Advances in the Research of Inhibitor-of-Apoptsis Protein XIAP in Chemoresistance
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摘要 细胞凋亡程度的降低是肿瘤发生的主要机制，造成肿瘤对化疗药物耐药的主要原因是化疗药物介导的细胞凋亡指数的下降。凋亡抑制蛋白在抑制细胞凋亡中起非常重要的作用，XIAP是IAP家族中抑制细胞凋亡的最主要成员。现总结了近年来对XIAP抗凋亡机制的研究及其在肿瘤化疗耐药方面的作用。 The decrease of apoptosis rate of cells is the main mechanism of cancer and the decline of apoptotic index by drug is an important reason in chemoresistance. The inhibitor of apoptosis protein plays important role in suppressing apoptosis of cells. XIAP is the most important member of IAP family. This article reviews the recent advances in the research of its mechanism and chemoresistance.
作者 李佩玲 杨帆 于海微
机构地区 哈尔滨医科大学附属第二医院妇产科
出处 《国际遗传学杂志》 CAS 2007年第1期61-63,共3页 International Journal of Genetics
关键词 细胞凋亡 XIAP 化疗耐药 Apoptosis XIAP Chemoresistance
分类号 R730 [医药卫生—肿瘤]
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参考文献19

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二级参考文献6

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国际遗传学杂志
2007年 第1期

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