核因子NF-κ_B与肝纤维化的关系研究现状

Progresses on the study of the relation between nuclear factor-κB and liver fibrosis

核转录因子-kB与肝纤维化的关系日益受到人们的关注。NF-kB能通过调控炎症因子和抗炎因子表达增加或减少来影响肝脏炎症反应的损伤修复,从而影响肝纤维化的发展,NF-kB还明显影响肝细胞和肝星状细胞的凋亡。目前已有多种NF-kB抑制剂用于治疗肝纤维化的研究。此文对NF-kB在肝纤维化时的作用以及抑制其活性的药物作一综述。

We have paid more attention to the relation between nuclear factor-κB and liver fibrosis. NF-κB can influence liver repair of inflammation damnification through control of inflammation factor and anti-inflammation factor expression, accordingly it can influence liver fibrosis aggravation, and as at that NF-κB can influence the apoptosis of hepatocytes and hepatic stellate cells. Now many NF-κB inhibitors have been study as therapy of liver fibrosis. The effect of NF-κB on liver fibrosis and NF-κB inhibitor are discussed below.