炎症性肠病与骨质疏松研究进展

Update on bone disease in inflammatory bowel disease

骨质疏松是炎症性肠病(IBD)患者常见但易被忽视的并发症之一。炎症性肠病患者骨质疏松的发病机制尚未完全明了,皮质类固醇激素的应用、炎性细胞因子的增加、维生素D的缺乏及遗传等众多因素均可能参与骨质疏松的发生。对于炎症性肠病患者并发骨质疏松者应及早诊断及治疗,早期干预可减轻IBD患者骨质疏松的发生与发展。

Patients with inflammatory bowel disease is at increased risk of developing osteopenia and osteoporosis. The pathogenesis of osteoporosis remains unknown. Corticosteroid use, proinflammatory cytokines, vitamin D deficiency and genetic factors are the risk factors for bone loss in ulcerative colitis and crohn disease. Early diagnosis and treatment is important for the patients with osteoporosis in inflammatory bowel disease.