大肠癌COX-2和BFGFR表达与Dukes分期,淋巴结转移之间的关系

Expression of COX-2 and BFGFR in carcinoma of the colon and rectum and the relationship between COX-2 and BFGFR expression and dukes stages and lymphaden metastasis

目的:研究COX-2、BFGFR在大肠癌中的表达和相互作用,以及它们与大肠癌Dukes分期,淋巴结转移之间的关系。方法:采用免疫组化SP法检测了49例手术切除的大肠癌及20例大肠增生性息肉组织中的COX-2、BFGFR表达。结果:COX-2、BFGFR在大肠癌中的表达阳性率分别为59.2%、65.3%,而增生性息肉的表达率分别为30.0%、35.0%,COX-2、BFGFR在大肠癌组织与增生性息肉中表达均有显著性差异。COX-2、BFGFR在大肠癌中表达分别与肿瘤Dukes分期、淋巴结转移之间具有显著性差异。大肠癌组织中COX-2、BFGFR表达二者间无相关性。结论:大肠癌组织中的COX-2、BFGFR表达水平增高,参与了大肠癌的发生发展过程,与大肠癌的预后有关,但二者的表达无相关性,提示它们在大肠癌的发生发展中所起的作用不同,是相互独立的作用因子。

Objective：To study the expression and interaction of Cyclooxygefiase-2 （COX-2） and basic fibroblast growth factor receptor （BFGFR） in carcinoma of the colon and rectum and the relationship between both COX-2 and BFGFR expression and Dukes stages and Iymphaden metastasis. Methods ：49 intestinal biopsy specimens were taken from patients with carcinoma of the colon and rectum and 20 hyperplastic polyp of intestine for controls ,the expression of COX-2 and BFGFR were detected by immunohistochemical staining（SP method）. Results： The positive rates of COX-2 and BFGFR were 59, 2 %, 65, 3 % in carcinoma of the colon and rectum respectively, and 30, 0 %, 35.0 % in hyperplastic polyp of intestine respectively, The positive rates of COX-2 and BFGFR were significantly differente between carcinoma group and polyp group of intestine. There was significant correlation among the expression of COX-2 and BFGFR and Dukes stage,lymph node metastasis, there was no significant relationship between the COX-2 and BFGFR expression. Conclusions： Excessive expression of COX-2 and BFGFR in carcinoma of the colon and rectum participates in carcinogenesis and development; COX-2 and BFGFR are related to prognosis; COX-2 was independent of BFGFR in carcinoma of the colon and rectum .