肾病综合征患者血浆脂蛋白(a)水平相关性分析

Plasma Lipoprotein(a) Levels in Patients with Nephritic Syndrome and Healthy People

目的:研究血浆脂蛋白(a)[Lp(a)]水平与肾病综合征(NS)的关系,探讨Lp(a)在肾病综合征合并心脑血管疾病中的作用。方法:用酶联免疫吸附法分别测定了61例肾病综合征患者与55名健康对照者的Lp(a)浓度,并同时测定了BUN、Scr、TG、TC、LDL-C和HDL-C的含量。结果:肾病综合征患者Lp(a)、BUN、Scr、TC、LDL-C水平均明显高于正常对照组,而HDL-C显著低于对照组,NS组Lp(a)浓度与BUN和Scr呈显著正相关,Lp(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性。结论:肾病综合征患者体内存在着Lp(a)等脂代谢紊乱的情况,高血浆Lp(a)水平是肾病综合征合并心脑血管疾病的独立危险因素之一。

Objective, To study the relationship between plasma lipoprotein（a） levels and the diseases of nephritic syndrome and investigate the clinical role of lipoprotein（a） in patients with cardiocerebrovascular arteriosclerosis caused by nephritic syndrome. Methods： Plasma concentrations of lipoprotein（a） were measured by enzyme-linked immunosorbent assay in 61 patients with nephritic syndrome and 55 healthy objects. At the same time the levds of BUN, Scr,TG, TC, LDL-C and HDL-C were measured with enzyme assay respectively. Results： The concentrations of Lp（a） , BUN, Scr, TC and LDL-C in patients with nephritic syndrome were significantly higher than that in healthy controls, however the concentrations of HDL-C in patients with nephritic syndrome was significantly lower. The plasma concentration of lipoprotein（a） was significantly positive correlating with plasma BUN concentration and Scr concentration. There was no correlation between LDL- C, HDL-C,TG,TC and Lp（a）. Conclusion.. Nephritic syndrome exists the circumstance of the disorder of lipid metabolism,such as Lp（a） etc. The high level of Lp（a） is an independent risk factor for cardiocerebrovascular arteriosclerosis caused by nephritic syndrome.