藻酸双脂钠对急性脑梗死患者纤维蛋白原、脂蛋白(a)的影响及疗效观察

Effects of Polysaccharide Sulfate on Fibrinogen and Lipoprotein (a) in Patients with Acute Cerebral Infarction

目的:探讨藻酸双脂钠(PSS)治疗急性脑梗死患者血液成分变化及疗效。方法:急性脑梗死患者158例,随机分为两组。对照组:78例,常规治疗;治疗组:80例,在常规治疗基础上,应用藻酸双脂钠注射液100mg加入0.9%氯化钠静脉滴注,每日一次,连续观察14d。对比分析二组治疗前后脂蛋白(a)、血脂、纤维蛋白原等血液流变学指标,并动态观察治疗前后临床神经功能缺损评分。结果:藻酸双脂钠可降低全血粘度、血浆粘度、血小板聚集率、纤维蛋白原及血清TC、TG、LDL,与治疗前比较有显著性改变(P<0.01或P<0.05);与对照组比较有显著性差异(P<0.01或P<0.05),但对脂蛋白(a)无影响;近期预后较常规治疗组好(P<0.05)。结论:藻酸双脂钠可改善血液高粘滞状态,起到降低纤维蛋白原、抗血小板聚集作用,可改善近期临床神经功能缺损程度。

Objective： To investigate the effects of polysaccharide sulfate （PSS） on blood component change in patients with acute cerebral infarction. Methods： 158 cases with acute cerebral infarction were divided randomly into control and treatment groups, 78 cases in control groups were treated routinely,while 100mg Polysaccharide sulfate injection was given by iv. drip, qd, in 80 cases of treatment group and also they took routine treatment. The treatment lasted for 14 days. Lipoprotein （a）, blood fat, fibrinogen of hemorrhedogy indexes and the neurologic function deficits of patients were studied before and after treatment. Results： Polysaccharide sulfate might reduce TC,TG,LDL, blood viseosity,fibrinogen and thrombocyte aggregation rate before and after treatment （P〈0.01 or P〈0. 05）. There were significant differences between control and therapy groups （P〈0.01 or P〈0.05） ,but didn＇t influence lipoprotein（a）. The recent prognosis was worse in control groups （P〈0.05） . Conclusion： Polysaccharide sulfate may improve blood viscosity and reduce fibrinogen and thrombocyte aggregation rate. It may improve the degree of neurologic function deficits recently.