血清基质金属蛋白酶9及高敏C反应蛋白与糖尿病肾病关系的探讨

Relationship of matrix metalloproteinase-9 and C-reactive protein with diabetic nephropathy

目的探讨血清基质金属蛋白酶9(MMP-9)及高敏C反应蛋白(hsC-RP)与糖尿病肾病(DN)发生的相关性。方法根据尿白蛋白/肌酐比值(UAlb/Cr)将80例2型糖尿病患者分为单纯糖尿病组(DM,UAlb/Cr<30mg/g,52例)和糖尿病肾病组(DN,UAlb/Cr≥30mg/g,28例),测定患者的MMP-9及hsC-RP水平。结果DN组患者的MMP-9浓度为(341±155)μg/L,hsC-RP浓度为(4·9±3·7)mg/L,分别显著高于DM组的(210±150)μg/L及(2·6±2·8)mg/L(P均<0·01);MMP-9及hsC-RP升高均与UAlb/Cr呈正相关(MMP-9=0·59UAlb/Cr+216·90,C-RP=0·015UAlb/Cr+2·51)。结论MMP-9和C-RP可能与DN的发生相关。

Objective To investigate the correlation of serum matrix metalloproteinase-9（MMP-9）and high sensitive C-reactive protein （hsC-RP） concentrations with diabetic nephropathy（DN）. Methods 80 T2DM patients were divided into two groups according to urinary albumin/creatinine ratio： diabetes mellitus（DM） group without nephropathy and diabetic nephropathy（DN） group. MMP-9 and hsC-RP were detected in all cases. Results MMP-9 in DN [（341 ± 155）μg/L] and hsC-RP [（4. 9 ±3. 7）mg/L] were significantly higher than those in DM group [（210 ± 150）μg/L and（2.6 ± 2. 8）mg/L] （P〈0. 01）. Conclusions Our results strongly suggest that high levels of serum MMP-9 and hsC-RP correlates positively with the development of diabetic nephropathy in T2DM.