胸水腺苷脱氨酶检测对结核性胸膜炎的诊断意义

Test for Adenosine Deaminase in Pleural Effusion for Diagnosing Tuberculous Pleuritis

目的:探讨胸水的腺苷脱氨酶(ADA)测定值对结核性胸膜炎的诊断意义和应用价值。方法:对436例住院的胸腔积液患者分别行结核菌素纯蛋白衍生物(PPD)试验,同时应用酶速率法检测胸水标本中ADA的活性,比较二者的灵敏度及特异度。所有患者试验前均未行抗结核治疗。结果:ADA试验灵敏度(96.1%)高于PPD(90.2%),二者差异有显著性(P<0.05)。结论:胸腔积液ADA含量的检测对于早期诊断及治疗结核性胸膜炎具有积极意义。

Objective： To study the relationship between the ADA rising in pleural effusion and tuberculous pleuritis, so as to prefer early chemotherapy. Methods： 436 cases with pleural effusion were tested with PPD and ADA activity was determined by enzyme kinetic analytical method respectively at the same time. All the patients had never been treated with chemotherapy for tuberculosis. Results： Statistical analysis suggest significant differences of sensitivity and specificity between ADA and PPD （P〈0.05）, the former sensitivity was higher （96.1%） than that of the later （90.2 %）. Conclusion： ADA test has active value in early diagnosis for tuberculous pleural effusion and its chemotherapy.