175例2型糖尿病患者线粒体基因变异分析

Analysis of mitochondrial DNA mutations in 175 cases with diabetes mellitus

本文采用PCR-RFLP及DNA测序方法对湖北省汉族人群无血缘关系的175例2型糖尿病患者及200例正常对照个体的线粒体DNA进行突变分析。两组间仅3394T→C突变发生率的差异有统计学意义。推测该位点变异与汉族人群中的线粒体糖尿病的发生发展有关。

PCR-RFLP and DNA sequencing were used to investigate mitochondrial DNA mutations in 175 cases with type 2 diabetes mellitus and 200 controls in Chinese Han population. There was significant difference in 3394 T→C mutation rate between two groups. The 3394 T→C mutation may be associated with DM.