2型糖尿病患者血清胰岛素样生长因子Ⅰ及其结合蛋白与大血管并发症的关系

The relationship of insulin-like growth factor-I and IGF-binding protein-1 with macrovascular complications in type 2 diabetic patients

2型糖尿病(T2DM)合并大血管病变者血清游离胰岛素样生长因子Ⅰ(IGF-I)水平较无大血管病变组降低(P<0·01),胰岛素样生长因子结合蛋白1浓度与WHR、胰岛素抵抗指数呈负相关。表明低IGF-I可能参与糖尿病大血管并发症的发生。胰岛素样生长因子结合蛋白1的浓度反映了胰岛素抵抗状态。

The level of serum free insulin-like growth factor-Ⅰ （IGF-Ⅰ） was significantly lower in type 2 diabetic patients with macrovascular complications than the patients without macrovascular complications （P〈 0.01）, IGF-binding protein-1 was negatively correlated with waist-hip ratio and HOMA-IR index, suggesting that the lower concentration of IGF-Ⅰ may be involved in the development of diabetic macrovascular complications. The concentration of IGFBP-1 may reflect insulin resistance status.