糖尿病周围血管病血管内皮祖细胞数量和功能的改变及其机制探讨

Changes of proportion and function of endothelial progenitor cells in type 2 diabetes mellitus with peripheral angiopathy and their possible mechanisms

糖尿病合并周围血管病患者内皮祖细胞数目减少,并与糖化血红蛋白水平呈负相关;增殖与黏附功能减低。糖尿病周围血管病变的发生可能与内皮祖细胞表达CXCR4减弱有关。

The proportion of EPCs in patients with type 2 diabetes mellitus was reduced and the amount of EPCs cells showed a negative relationship with the patients＇ HbA1c level. The functions of proliferative and adherent abilities of them were attenuated. The group of T2DM with peripheral angiopathy had a lower expression of CXCR4 mRNA as compared with control and T2DM. The mechanism of diabetic peripheral angiopathy may be correlated with the attenuation of the expression of CXCR4.