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大麻素、大麻受体与胶质瘤细胞凋亡 被引量:1

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摘要 大麻是一种草本植物。大量的动物实验研究证明,大麻类物质具有止痛、镇静、抗痉挛、抗呕吐、抗青光眼以及抗高血压等多种药理作用。由于机体对大麻类物质有一定的耐受性和成瘾性,因此其临床应用受到严格限制。70年代,有人报道,大麻可能会降低机体抗病毒感染的能力,甚至导致免疫无应答综合征。90年代初,大麻类物质的中枢型受体和外周型受体相继克隆成功.几种内源性大麻先后被发现。近些年来,国外有学者开始认识到大麻素能诱导神经系统肿瘤(特别是胶质瘤)细胞的凋亡,
作者 马超 袁先厚
出处 《中国临床神经外科杂志》 2007年第3期185-189,共5页 Chinese Journal of Clinical Neurosurgery
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  • 2Scheurer ME,Tortolero-Luna G,Adler-Storthz K.Human papillomavirus infection:biology,epidemiology,and prevention[J].Int J Gynecol Cancer,2005,15(5):727-746.
  • 3Ramer R,Hinz B.Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1[J].J Natl Cancer Inst,2008,100(1):59-69.
  • 4Sami Sarfaraz,Farrukh Afaq,Vaqar M.Adhami and Hasan Mukhtar.Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer[J].American Association for Cancer Research,2005,65:1635-1641.
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  • 6Sami S,Vaqar M,Deeba N,et al.Cannabinoids for cancer treatment:progress and promise[J].Cancer Res,2008,68(2):339-342.
  • 7Blázquez C,Carracedo AK,Barrado LL,et al.Cannabinoid receptorsas novel targets for the treatment of melanoma[J].FASEB J,2006,12 (20):1-10.
  • 8赵梓纲,赵华,李恒进.大麻素Ⅱ型受体(CB2)在人皮肤及皮肤恶性肿瘤的组织分布[J].细胞与分子免疫学杂志,2008,24(1):67-68. 被引量:2

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