海南省陵水县黎族人群红细胞葡萄糖-6-磷酸脱氢酶缺乏症基因频率调查

INVESTIGATION ON GENE FREQUENCY OF ERYTHROCYTE GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCYIN LI POPULATION IN LINGSHUICOUNTY,HAINANPROVINCE

目的：在疟疾流行区建立红细胞葡萄糖－６－磷酸脱氢酶缺乏者个人档案，以预防伯氨喹溶血反应的发生。方法：用四氮唑蓝（ＮＢＴ）法测定红细胞葡萄糖－６－磷酸脱氢酶活性。结果与结论：２４３９名黎族人群红细胞葡萄糖－６－磷酸脱氢酶缺乏症基因频率为０．１７５９，其女性杂合子发生率为２８．３３％，纯合子发生率为３．０９％。

AIM:To establish a file on glucose 6 phosphate dehydrogenase (G6PD) activity in Li population in malarious area for preventing primaquine hemolysis. METHOD:Erythrocyte G6PD activity was determined by using NBT method. RESULTS:Among 2439 Li residents examined,429 were found to be G6PD deficient.The gene frequency of G6PD deficiency was 0.1759. The incidence of female heterozygotes and homozyotes was estimated as 28.33% and 3.09%,respectively. CONCLUSION:The study provides evidence for the G6PD deficiency in Li residents in Lingshui County,Hainan Province.