遗传性非息肉病性大肠癌（附10个家族报告）

Hereditarynonpolyposiscolorectalcancer.Areportof10familiesMo

遗传性非息肉病性大肠癌又称Ｌｙｎｃｈ综合征。患者之子女中５０％将受遗传而发病。在全部大肠癌患者中约５％属该病。在确诊的１０个Ｌｙｎｃｈ综合征家族。有３７例患大肠癌。平均发病年龄为４４．８岁（２０－７３岁）。３７例共已患５１个大肠癌，其中８２．３％为结肠癌，５６．９％位于脾曲近侧结肠，２０．２％有多原发大肠癌。文章强调了及早识别该病与随访的意义，以及诊断、治疗的特点。

Hereditarynonpolyposiscolorectalcancer(HNPCC)isalsocalledLynchsyndrome.50%* ofpatients'childrenwillbecomevictumsofcolorectalcancer.Itaccountsfor5%* oftotalcolorectalcancer.Thereareseveralcharacteristicfeatureswhicharefullypresentedinthepaper.Weascertained10familieswithLynchsyndrome.Therewere37casesofcolorectalcancer,themeanageofonsetwas44.8years(20-73years).In37cases,51colorectalcancerswerefound,amongwhich82.3%*妉ocatedincolon,56.9%* proximaltosplenicflexure.20.2%* hadmultipleprimarycolorectalcancer.Thearticleemphasizedonthesignificanceofearlyrecognitionandfollow-upstudy,theircharacteristicfeaturesindiagnosisandwayoftreatment.