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肝细胞癌患者血清乙型肝炎病毒X区及前S/S区基因变异特点 被引量:5

Characteristics of mutations in hepatitis B virus X gene and preS/S gene isolated from patients with HBV-related hepatocellular carcinoma
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摘要 HCC是常见的恶性肿瘤之一。众多流行病学资料显示,慢性HBV感染是HCC的主要病因。HBV感染致HCC的确切机制尚未彻底阐明,有学者认为HBV基因变异与肝癌发生发展密切相关。HBVC区变异与HBeAg血清转换及肝炎活动相关.与HCC发生关系不大。而P基因区变异与抗病毒药物耐药有关。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2007年第2期146-148,共3页 Chinese Journal of Hepatology
关键词 肝细胞 肝炎病毒 乙型 基因 突变 X基因 前S/S基因 Carcinoma, hepatocellular Hepatitis B virus:Genes: Mutation X gene: PreStS gene
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