不同糖耐量状态者血清SICAM-1和SVCAM-1水平与炎症相关性研究

Study of serum levels of soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 and their relationship with inflammation in subjects with various glucose tolerance

按口服葡萄糖耐量试验结果，将研究对象分为正常糖耐量（NGT）组、单纯空腹血糖受损（IFG）组、单纯糖耐量受损（IGT）组、IFG与IGT并存（IFG／IGT）组及2型糖尿病（DM）组。采用酶联免疫吸附法（ELISA）分别检测上述人群的血清可溶性细胞间黏附分子1（SICAM-1）、可溶性血管细胞黏附分子1（SVCAM-1）和超敏C反应蛋白水平（hr-CRP），并与糖脂代谢指标和稳态模型胰岛素抵抗指数（HOMA-IR）作相关性分析。结果显示，血清SICAM-1、SVCAM-1和hs-CRP水平按分组顺序逐组升高，提示2型DM的发病过程与内皮细胞损伤和炎症状态有关。

According to oral glucose tolerance test （OGTY） subjects were divided into normal glucose tolerance （NGT） group, impaired fasting glucose （IFG） group,impaired glucose tolerance （IGT） group, IFG and IGT （IGT/IFG） group and type 2 diabetes （DM） group. The concentrations of serum soluble intercellular adhesion molecule-1 （ SICAM-1 ）, soluble vascular cell adhesion molecule-1 （ SVCAM-1 ） and high sensitivity Creactive protein （hs-CRP） were measured in these subjects by ELISA and their associations with parameters of glucose and lipid metabolism and homeostasis model assessment insulin resistance index （HOMA-IR） were analysed. The results showed that serum levels of SICAM-1, SVCAM-1 and hs-CRP were increasing according to the order of groups, suggesting that the pathogenesis of type 2 DM is associated with endothelial damage and jnflammation.