血清嗜铬粒蛋白A在前列腺癌诊断中的临床意义

Clinical significance of serum chromogranin A in diagnosis of prostate cancer

目的:探讨嗜铬粒蛋白A(CgA)在前列腺癌(PCa)中的表达及意义。方法:采用放射免疫方法测定27例前列腺癌、27例前列腺增生症患者及5例健康志愿者的血清CgA、前列腺特异性抗原(PSA),分析各组CgA和PSA的水平。结果:PCa患者血清CgA(98.7±69.42),与健康对照组(32.68±26.58)及BPH组(44.7±40.86)比较有显著意义(P<0.05)。血清CgA水平随癌分期的升高而升高,D期患者血清CgA水平明显高于正常对照组及其他各期PCa(P<0.01)。结论:血清CgA水平可应用于前列腺癌的诊断,尤其对PSA阴性或伴有远隔转移的病例具有重要意义。

Objective：To evaluate the application of chromogranin A （CgA） as a marker in the diagnosis of prostate cancer. Methods：Serum CgA and serum prostate-specific antigen （PSA） were detected by immunoradiometric essay in 27 cases of prostatic carcinoma ,27 cases of benign prostate hyperplasia （BPH）and 5 cases of healthy subjects. Results：Serum CgA （98.7±69.42） in patients with prostatic carcinoma was significantly higher than that in healthy subjects （32.68±26.58） and in patient with BPH （44.7 ±40.86）（P〈0.05）,and it increased with escalation of clinical stage .Serum CgA at D stage was significantly higher than that in bealthy subjects and patient at B and C stage of prostate cancer （P〈0.01）.The combined assay of serum PSA and CgA could raise the detection rate of prostate cancer .The sensitivity of parallel trials reached 85.2% and the specificity of serial trials reached 96%. Conclusions：The determination of serum levels of CgA is useful in the diagnosis of prostatic cancer, especially for patients who are PSA negative or have distant metastasis .