乙肝病毒PreS1抗原的临床应用

Clinical application value of HBV PreS1 antigen

目的:评价检测乙肝病毒PreS1抗原的临床应用价值.方法:将临床送检的1000份乙肝病毒表面抗原(HBsAg阳性的血清标本进行PreS1抗原检测,同时用FQ-PCR进行HBV-DNA测定.结果:PreS1总阳性率为52.0%,HBV-DNA阳性率为50.8%,HBeAg阳性率为21.0%.PreS1总阳性率明显高于HBeAg阳性率.PreS1与HBV-DNA的总符合率为94.4%.结论:PreS1抗原作为乙肝感染和复制的血清学指标敏感性高于HBeAg,对提示乙肝患者的病情发展和转归有重要临床意义.PreS1可以作为一项新的乙肝病毒复制的传染性指标.

AIM： To evaluate the clinical significance of detecting PreS1 antigen of hepatitis B virus （HBV）. METHODS： HBsAg positive serum specimens （n = 1000） from inpatients and outpatients were collected, then detected for PreS1 antigen and HBV DNA by fluorescence quantitative pelymerase chain reaction （FQ-PCR）. RESULTS： The total PreS1 positive rate was 52.0%, the HBV-DNA positive rate was 50. 8%, and the HBeAg positive rate was 21.0%. The total positive rate of PreS1 was higher distinctly than that of HBeAg. The total accordance rate between PreS1 and HBV-DNA was 94. 4%. CONCLUSION： PreS1 is more sensitive than HBeAg when as a serological index of HBV infection and reproduction. Determination of PreS1 has a great application value in diagnosis and treatment of hepatitis B. PreS1 could be taken as a new serological indicator for infectivity and replication of HBV.