抗血小板治疗对脑梗死患者血小板活化标记物表达的影响

Influence of anti-platelet therapy on the expressions of platelet activation markers in patients with acute cerebral infarction

目的:探讨急性脑梗死患者血小板活化状态及抗血小板药物阿司匹林和氯吡格雷治疗对血小板活化状态的影响,为急性脑血管病的预防和治疗提供可靠的理论依据.方法:采用流式细胞检测方法,对急性脑梗死血小板活化标记物P选择素(CD62P)及PAC-1进行检测研究.结果:急性脑梗死患者血小板活化标记物表达明显高于正常对照组,脑梗死伴糖尿病及高血压者血小板活化标记物表达明显高于单纯脑梗死组,阿司匹林及氯吡格雷治疗能明显抑制血小板活化标记物表达,但二者在治疗后相比较无统计学差异.结论:急性脑梗死疾病发生过程中,血小板活化起了主要作用,且高血压及糖尿病有促进体内血小板活化的作用,加重脑血管病的发生,阿司匹林及氯吡格雷在治疗急性脑梗死中能明显抑制血小板活化,在一定程度上阻断血小板活化过程,预防复发.

AIM： To study the influence of different anti-platelet drugs on the expressions of platelet activation markers in patients with acute cerebral infarction aspirin and clopidogrel and provide reliable theoretical references for the prevention and therapy of acute cerebral infarction. METHODS： Flow cytometry was used to examine CD62P and PAC-1, two platelet activation markers in patients with cerebral infarction. RESULTS： The expressions of platelet activation markers in patients with acute cerebral infarction patients was obviously higher than that in normal control group. The expression of platelet activation markers in acute cerebral infarction patients with diabetes and hypertension was much higher than that in acute cerebral infarction patients without diabetes and hypertension. Both aspirinand clopidogrel could inhibit the expression of platelet activation markers, but there was no remarkable difference between them. CONCLUSION： The activation of platelet plays a main role in the pathogenesis of acute cerebral infarction. Diabetes and Hypertension can aggravate the occurrence of acute cerebral infarction by enhancing the activation of platelet Both Aspirin and Clopidogrel could inhibit the expression of platelet activation markers and prevent relapse in acute cerebral infarction patients.