原发性肺淋巴瘤和肺淋巴瘤样肉芽肿的临床病理与治疗分析

Clinicopathological characteristics and therapy of primary pulmonary lymphoma and lymphomatoid granulomatosis

目的:探讨原发性肺淋巴瘤(PPL)和肺淋巴瘤样肉芽肿(PLG)的临床病理和治疗预后.方法:回顾分析10例PPL和2例PLG的临床病理特征和治疗经验.12例临床病例均经过手术治疗和手术后病理证实.结果:PPL和PLG分别占同期手术的肺恶性肿瘤的0.5%(10/1887)和0.1%(2/1887).8例手术后病理诊断为非霍奇金淋巴瘤(B细胞型),其中2例在手术后3a内死亡;2例为霍奇金病,均在手术后3a内死亡.2例为PLG.结论:PPL和PLG在临床上极少见,它们都起源于支气管黏膜相关的淋巴组织,包括支气管黏膜下组织和动静脉周围的淋巴组织,但各自有其典型的临床病理学特征.治疗PPL包括手术和手术后放疗、正规化疗.PLG以手术治疗为首选.

AIM： To explore the clinicopathological characteristics and therapentic strategies of primary pulmonary lymphoma （PPL） and lymphomatoid granulornatosis （PLG）. METHODS： The elinieopathologieal characteristics and the experience of surgical treatment of 10 cases of PPL and 2 of PLG were analyzed retrespectively. All eases were operated and pathologically confirmed. RESULTS： PPL accounted for 10 （0. 5%） of 1887 cases of primary pulmonary malignant carcinoma in the same period, and PLG for 2 （0. 1% ） of 1887 cases. Eight eases were non-Hedgkin＇s lymphoma （B-type） confirmed by pathology, of them 2 cases died within 3 years postoperatively. The other eases were Hedgkin＇s disease and died within 3 years postoperatively. Two eases were PLG. CONCLUSION： PPL and PLG are clinically rare with typical elinieopathologieal characteristics respectively. The correct diagnosis is difficult preoperatively. Managment modalities for PPL include surgical theatment, postoperative radiotherapy and chemotherapy. Surgical treatment is the first choice for PLG.