摘要
近二十年,再生障碍性贫血(AA)的研究取得重大突破。中国AA年发病率约0.73/10万,病毒感染等危险因素与AA发病明显相关。AA已由“骨髓衰竭综合征”逐步被认知为自身免疫性T细胞功能异常相关的骨髓衰竭症。诊断AA关键依据骨髓造血功能低下、T细胞功能亢进及除外检查。治疗AA以强化免疫抑制和促造血为主且疗程必须充分。AA是可以治愈的。
There were great break through in the studies on aplastic anemia in China during the past 20 years. The annual incidence of aplastic anemia in China was about 0. 73 per one hundred thousand population. The risk factors, particularly virus infection, were associated with the onset of aplastic anemia. The pathogenesis of aplastic anemia was recognized as that the marrow failure was resulted mainly by autoimmunic T cell attack through lymphokine induced apoptosis. Aplastic anemia, an autoimmunic marrow failure rather than marrow failure syndromes, should be diagnosed based on marrow failure, T cell over function and exclusion of other similar diseases. Long enough intensive immunosuppressive therapy combined with hemopoietic stimulating factors was proven to be effective on aplastic anemia which might be cured.
出处
《基础医学与临床》
CSCD
北大核心
2007年第3期233-237,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(30470749)