传导性失语联系中断学说的研究

Study of the Disconnection Theory in Conduction Aphasia

目的通过扩散张量成像分析,验证传导性失语复述障碍的联系中断学说。方法选择5例病变部位累及弓状纤维束的传导性失语患者及5例健康志愿者,采用北京大学第一附属医院神经内科制定的利手评定标准,进行利手评定。应用扩散张量成像分析入选病例的弓状纤维束,比较健康志愿者与传导性失语患者的异同。结果5例传导性失语患者及5例健康志愿者均为右利手,与健康志愿者比较,传导性失语患者的弓状纤维束均不同程度受累。结论传导性失语复述障碍的联系中断学说是传导性失语发病机制之一。

Objective To test and verify the disconnection theory in conduction aphasia with diffusion tensor imaging. Methods 5 conduction aphasia cases and 5 volunteers carried out handedness assessment of aphasia battery of China meanwhile 5 conduction aphasia cases were studied using oral fluent test. We studied theses case＇ s arcuate fasciculus with diffusion tensor imaging. Results All of these cases were right handedness. DTI showed that the fibers arcuate fasciculus were damaged at different levels compared with control group. Conclusion The disconnection between Broca＇s area and Wernicke＇s area is one of mechanisms in conduction aphasia.