非晶金刚石膜在口腔医学材料中的应用

Use of an amorphous diamond film as dental material

采用带过滤的阴极真空等离子电弧镀膜技术,对口腔牙用聚甲基丙烯酸甲酯(PMMA)树脂及纯钛材料进行了表面镀覆非晶金刚石膜的改性处理,获得了镀覆非晶金刚石膜的PMMA树脂和镀覆非晶金刚石膜的纯钛口腔牙用材料。通过细胞培养和动物实验,考察了非晶金刚石膜的生物相容性。采用HA-1型涂层附着力划痕试验仪研究了非晶金刚石膜与PMMA树脂和与纯钛的结合力及镀覆非晶金刚石膜PMMA树脂和镀覆非晶金刚石膜纯钛的耐磨性能。在人工唾液中模拟口腔环境进行电化学分析测试了镀覆非晶金刚石膜纯钛材料的耐腐蚀性能。借助SEM观察了镀覆非晶金刚石膜纯钛材料的表面形貌。实验结果显示:非晶金刚石膜细胞毒性评级为0级,溶血率为3.08%,短期全身毒性试验为阴性;PMMA树脂经极化预处理后可镀覆结合力为(10.86±0.79)N的非晶金刚石膜;镀覆非晶金刚石膜纯钛表面自腐蚀电位和过钝化电位正移。表明非晶金刚石膜作为生物材料,其生物安全性、耐腐蚀性及镀膜结合强度达到口腔医用材料的要求。

The biocompatibility and surface characteristics of. dental materials surface-modified by an amorphous diamond film were investigated. The dental materials are poly（ methyl methacrylate） （PMMA） and pure titanium and the amorphous diamond film surface was produced by a plasma assisted cathode arc discharge under vacuum. The biocompatibility was evaluated by cell cultivation and animal implants and the wearability of the PMMA tooth after modification was analyzed by a scratching test. The surface characteristics of the film were characterized by SEM. The corrosion resistance of the surface of pure titanium dental material after the surface modification was investigated by the electrochemical analysis of a simulated oral cavity filled with artificial saliva. Results show that the toxicity of the amorphous diamond film modified dental materials is zero, and the hemolysis ratio is 3.08 %. After polarization pre-treatrnent, the PMMA artificial tooth coated with an amorphous diamond film has a maximium adhesion force of 10.86 ±0.79 N. The self-corrosive potential and the over-passivation potential of the pure titanium after the surface modification were increased. These results demonstrate that coating the surface of dental materials with a diamond film meets the requirements of biocompatibility, anticorrosion and adhesion strength.