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子宫肉瘤分子标记物临床应用的研究进展 被引量:3

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摘要 随着人类基因组时代的到来,肿瘤病因学和药物基因组学的研究不断深入,研究肿瘤与分子标记物的关系在肿瘤诊断、判断预后及分子靶向治疗上的意义越来越大。目前药物研制的新模式是新基因-新靶点-创新药物出现。子宫肉瘤发病率低,但恶性程度高,治疗效果不理想。诊断现主要依靠组织形态学及免疫组织化学,随着国内外诊断子宫肉瘤分子标记物的逐渐增多,为研究其诊断、治疗及判断预后提供了重要的指导价值。现将目前与子宫肉瘤有关的分子标记物的最新研究进展作一综述。
出处 《现代妇产科进展》 CSCD 北大核心 2007年第2期140-142,共3页 Progress in Obstetrics and Gynecology
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  • 1Sagawa Y, Nishi H, Isaka K, et al. The correlation of TERT expression with c-myc expression in cervical cancer[ J].Cancer Lett ,2001,168 :45-50
  • 2Gokaslan H, Turkeri L, Kavak ZN, et al. Differential diagnosis of smooth muscle tumors utilizing p53, PTEN and Ki-67 expression with extrogen and progensterone receptors[ J ]. Gynecol Obstet Invest,2005,59:36-40
  • 3Anderson SE, Nonaka D, Chuai S, et al. p53, epidermal growth factor,and platelet-defived growth factor in uterine leiomyosarcoma and leiomyomas [ J ]. Int J Gynecol Cancer,2006,6:849-853
  • 4Abargel A, Avinoach I, Kravtsov V, et al. Expression of p27 and p53:comparative analysis of uterine carcinosarcoma and endometrial carcinoma[ J ]. Int Gynecol Cancer,2004,14:354-359
  • 5Zhai YL, Kobashi Y, Mori A, et al. Expression of cyclins and cyclin-dependent kinanses in smooth muscle tumors of the uterus [ J ]. Int J Cancer, 1999,84:244-250
  • 6Bodner K, Bodner-Adler B, Kimerger O, et al. Bcl-2 expression and other clinicopathologic parameters in uterine leiomyosarcoma [ J ]. J Soc Gynecol Investig, 2004, 11 :187-191
  • 7Sawada M, Tsuda H, Kimura M, et al. Different expression patterns of KIT, EGFR, and HER-2 oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma[ J ]. Cancer Sci ,2003,94:986-991
  • 8Wang L, Felix JJC, Lee JL,et al. The proto-oncogene c-kit is expression in leiomyosarcomas of the uterus [ J ]. Gynecol Oncol 2003,90:402-406
  • 9Geller MA, Argenta P, Bradley W, et al. Treatment and recurrence patterns in endometrial stromal sarcomas and the relation to c-kit expression [ J ]. Gynecol Oncol,2004,95:632-636
  • 10Rusning RS, Shajahan S, Chendil D, et al. Uterine sarcomas express KIT protein but lack mutations in exon 11 or 17 of c-kit[ J]. Gynecol Oncol,2003,91:9-14

同被引文献13

  • 1盖文君,姚宏.子宫平滑肌肿瘤p16抑癌基因表达的定量研究[J].山西医药杂志,2007,36(7):597-598. 被引量:1
  • 2van Beerendonk HM, Rozeman I.B, Taminiau AH. Molecular analysis of the INK4A/INK4A- ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for turnout progression [J] . J Pathol, 2004, 202 (3) : 359.
  • 3Obana K, Yang HW, Piao HY. Aberrations of p16INK4A, pl4ARF and pl5INK4B genes in pediatric solid tumors [J]. Int J Oncol, 2003, 23 (4): 1151.
  • 4Bodner - Adler B, Bodner K, Czerwenka K et al. Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis[J]. Gynecol Oncol, 2005, 96 (1): 62.
  • 5Tsoumpou I, Arbyn M, Kyrgiou M et al. p16 (INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta - analysis[J]. Cancer Treat Rev, 2009, 35 (3) : 210.
  • 6Yoo J, Park SY, Kang SJ et al. Altered expression of GI regulatory proteins in human soft tissue sarcomas [J].Arch Pathol La Med, 2002, 126 (5): 567.
  • 7Szabo I, Szantho A, Csabay I, et al. Color Doppler uhramnography in the differentiation of uterine sarcomas from uterine leiomyomas [ J 1. Eur J Gynecol 0ncol,2002,23 ( 1 ) :29 - 34.
  • 8Robert L, Giuntoli RL, Daniel S, et al. Retrospective review of 208 patients with leiomyosarcoma of the uterus : prognostic indicators, sur- gical management, and adjuvant therapy [ J ]. Gynecologic Oncology, 2003,78(4) :460 -469.
  • 9Kapp DS, Shin JY, Chan JL. Prognostic factors and survival in 1396 patients with uterine leiomyosarcomas:emphasis on impact of lymph- adenectomy and oophorectomy [ J ]. Cancer, 2008, 112 ( 4 ) : 820 - 830.
  • 10Giuntoli RL, Matzinger DS, Di Marco CS, et al. Retrospcetive review of 208 patients with leiomyosarcoma of the uterus : prognosis indicate- ors, surgical management, and ajuvant therapy [ J 1. Gyneeol Oncol, 2003,89(3) :460-469.

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