阿立哌唑对女性精神分裂症患者生活质量的影响

A comparative study on quality of life of female schizophrenics treated with aripiprazole

目的:探讨阿立哌唑与利培酮对女性精神分裂症患者生活质量的影响。方法:对60例女性精神分裂症患者随机分为两组,分别给予阿立哌唑、利培酮治疗6个月。用阳性症状与阴性症状量表(PANSS)评定精神症状,副反应量表(TESS)评定不良反应,生活质量综合评定问卷(GQOLI)评定生活质量。结果:治疗6个月后阿立哌唑对精神分裂症阳性症状与阴性症状的改善与利培酮相似,两组间PANSS评分差异无显著性(P>0.05)。阿立哌唑组不良反应在锥体外系(EPS)、体重增加、月经失调等少于利培酮组,两组差异有显著性(P<0.01)。阿立哌唑组GQOLI总分、躯体健康维度、心理健康维度、社会功能维度较利培酮组有显著改善(P<0.01)。结论:阿立哌唑组患者生活质量优于利培酮组。

Objective：To compare the quality of life of female schizophrenics treated with aripiprazole and risperidone. Methods ：60 cases of female schizophrenics were randomly divided into aripiprazole group and risperidone group. The positive and negative symptom scale（PANSS） , treatment emergent symptom scale（TESS）, general quality of life inventory（GQOLI） were assessed by all subjects to determine the efficacy, side effects and life quality respectively for 6 months. Results： At the end of 6 months, aripiprazole and risperidone had similar effects on positive and negative symptoms of female schizophrenia. There was no significant difference between the score of PANSS in two groups （ P 〉 0.05 ） , The side effects of aripirazole group in extra pyramidal system （EPS） , weight gain, menstrual dysfunction were less than risperidone group （ P 〈 0.01 ）. Compared with the risperidone group, the total score of GQOLI and factor scores of physical function, mental health and social function decreased significantly （P 〈 0.01 ）. Conclusions： Female schizophrenics treated with aripiprazole have better quality of life than those with risperidone.