摘要
β-连环蛋白（β-catenin）是近年来发现的一种信号传导分子，它可通过以下途径来调节肠上皮干细胞的增殖分化：（1）β-连环蛋白可在Wnt途径失活时，通过磷酸化和泛素化而降解，从而维持胞浆内低水平；Wnt途径激活时，磷酸化和泛素化被抑制，β-连环蛋白在胞浆内积聚，随后进入核内与Tcf-4结合成转录复合体，并促进与肠干细胞增殖有关的基因表达。（2）β-连环蛋白还可通过酪氨酸残基的磷酸化与去磷酸化实现其活性和量的调节，并且在调控肠干细胞增殖及其子代细胞的分化、迁移过程中起着重要的作用。
It has been discovered that β-catenin is a molecule for signal transduction, and it regulates the stem cell of enteric epithelium via follow pathes： （ 1 ） When β-catenin was deactive via the Wnt pathway, it was degraded by phosphorylation and ubiquitin and therefore maintained low level in cytoplasm; When it was activated via the Wnt pathway, phosphorylation and ubiquitin were inhibited. And β-catenin was accumulated in cytoplasm and thereafter it entered nuclear to form transcription complexes that facilitated gene expression related to proliferation of enteric stem cells. （2） β-catenin could also regulate its activity and quantity by phosphorylation of the tyrosine residues and dephosphorylation, and it plays important roles in the regulation of proliferation of enteric stem cells and the differentiation and migration of daughter cells.
出处
《国际外科学杂志》
2007年第2期104-107,共4页
International Journal of Surgery
基金
广东省自然科学基金资助项目（No.032901）
