代谢综合征的临床特征及其危险因素分析

Analysis on the clinical characteristics and risk factors of metabolic syndrome

目的探讨成人代谢综合征(MS)的临床特征及MS发生的相关危险因素。方法对20岁以上健康体检者807例进行调查,应用logistic回归分析的方法进行MS的危险因素分析。结果(1)MS检出率为24.0%(194/807),40岁以上MS的检出率明显升高,女性发病高峰较男性提前。(2)本组人群MS相关疾病的检出率:糖尿病(DM)或糖调节受损(IGR)为25.4%,高血压为23.9%,血脂紊乱为30.1%,超重/肥胖为35.1%。男性高血压、超重/肥胖显著高于女性。(3)MS患者最多见的表现形式为超重/肥胖+高血糖+血脂紊乱,占32.5%,其次为超重/肥胖+高血压+血脂紊乱,占27.8%。其中超重/肥胖占89.7%(174/194)。(4)胰岛素抵抗在MS及各组分的伴发频率分别为:MS54.1%、DM69.1%、IGR50.0%、高血压41.5%、血脂紊乱48.6%、超重或肥胖43.8%。(5)进入logistic回归模型的因素有:糖尿病家族史、休闲体力活动、吸烟、经济收入、高盐饮食、年龄、性别7项。结论随着年龄的增长,MS的检出率有增高趋势;超重/肥胖是构成MS最常见的组分;IR在MS及各组分中普遍存在;MS发病与不良生活方式有关。

Objective To analyze the clinical characteristics and risk factors of metabolic syndrome（MS） among adults aged≥20 years. Methods Totally 807 subjects were analyzed in this study. MS was diagnosed according to definition by Chinese Medical Association in 2004. Logistic regression were used to identify risk factors of MS. Results （1） The incidence of MS was 24. 0% （194/807） which increased with aging, especially in adults over 40 years old. The peak time of incidence in female was earlier than in male. （2） The incidences of MS-associated metabolic diseases were 25.4% in diabetes/impaired glucose regulation （IGR）, 23.9% in hypertension, 30. 1% in dyslipidoses, 35. 1% in over weight/obesity. The incidences of hypertension and over weight /obesity were higher in male than in female. （3） The MS representations were over weight/obesity＋ hyperglycemia ＋ dyslipidosis （32.5 %）, over weight/obesity＋ hypertension＋ dyslipidosis （27.8 % ）, over weight/obesity（89.7%）. （4）The incidence of insulin resistance（IR） was 54. 1% in MS,69.1% in diabetes, 50. 0N in impaired glucose regulation,41.5% in hypertension,48.6% in dyslipidemia,43.8% in over weight or obesity. （5） Family history of diabetes, smoking, leisure activity, income, taking more salt, age, sex were risk factors of MS. Conclusions The incidence of MS is increased with aging. Over weight and obesity are the most common components in MS. IR is common in MS and its components. MS is associated with bad life-styles.