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老年2型糖尿病脂联素与血小板活化和动脉粥样硬化相关性研究 被引量：2

Study of correlations of serum adiponectin with platelet activation and carotid atherosclerosis in elderly type 2 diabetic patients
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摘要 50例2型糖尿病(T2DM)颈总动脉内膜中层厚度(IMT)、血小板活化和胰岛素抵抗指数(HOMA-IR)高于对照组,脂联素与血小板活化、颈总动脉IMT和HOMA-IR呈负相关。低脂联素血症与IR和动脉粥样硬化相关,血小板活化(CD62P、CD41+CD11b)是影响T2DM脂联素水平危险因素之一。 IMT platelet activation and HOMA-IR in 50 cases with T2DM were significantly higher than in normal controls, and serum adiponectin level in T2DM was negatively correlated with platelet activation,IMT and HOMA-IR. Hypoadiponectinemia was associated with insulin resistance and atherosclerosis. The platelet activation with increased CD62p and increased （CD41 ＋ CD11b） might be one of the risk factors for predicting adiponectin in T2DM.
作者 邹继红 李洁 谢玉兰 寿伟璋
机构地区 东南大学附属中大医院
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2007年第2期102-103,共2页 Chinese Journal of Diabetes
关键词 糖尿病 2型 脂联素 血小板活化 动脉粥样硬化 Type 2 diabetes mellitus Adiponectin Platelet activation Atherosclerosis
分类号 R587.1 [医药卫生—内分泌] R543.5 [医药卫生—心血管疾病]
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参考文献3

  • 1Kern PA,Di Gregorio GB,Lu T,et al.Adiponectin expression from human adipose tissue:relation to obesity,insulin resistance,and tumor necrosis factor-alpha expression.Diabetes,2003,52:1779-1785.
  • 2Arita Y,Kihara S,Ouchi N,et al.Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.Circulation,2002,105:2893-2398.
  • 3Hirose H,Kawai T,Yama mato Y,et al.Effects of pioglitazone on metabolic parameters,body fat distribution,and serum adiponectin levels in Japanese male patients with type 2 diabetes.Metabolism,2002,51:314-317.

同被引文献18

  • 1江彤,薛海波,卢承德.2型糖尿病患者血清抵抗素水平与血管内皮功能紊乱的关系[J].青海医药杂志,2007,37(9):2-4. 被引量：1
  • 2倪一虹,陈丽,栗华,陈诗鸿,宋惠玲.血清Resistin水平与2型糖尿病大血管并发症的关系[J].山东大学学报（医学版）,2004,42(4):428-431. 被引量：2
  • 3陈贵海,孙建,陈利国.肥胖与血瘀证形成的相关性(英文)[J].中国临床康复,2005,9(11):206-209. 被引量：7
  • 4Gensini GG. A more meamngful scoring system for determining the se- verity of coronary heart disease [ J l. Am J Cardiol, 1983,51 (3) :606.
  • 5Citirik M, Beyazyildiz E, Simsek M, et al. MPV May reflect subcinical platelet activation in diabetic patients with and without diabetic reti- nopathy[ J]. Eye,2015,29(3) :376 -379.
  • 6Ulutas KT, Dokuyucu R, Sefil F, et al. Evaluation of mean platelet vol- ume in patients with type 2 diabetes mellitus and blood glucose regula- tion: a marker for atherosclerosis [ J ]? Int J Clin Exp Med, 2014,7 (4) :955 -961.
  • 7Sansanayudh N, Anothaisintawee T, Muntham D, et al. Mean platelet volume and coronary artery disease:a systematic review and meta-a- nalysis [ J ]. lnt J Cardiol, 2014,175 ( 3 ) : 433 - 440.
  • 8Minuz P, Patrignani P, Gaino S, et al. Increased oxidative stress and platelet activation in patients with hypertension and renovasculardis- ease[ J]. Circulation ,2002,106(22 ) :2800 - 2805.
  • 9Citirik M, Beyazyildiz E, Simsek M, et al. MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic reti- nopathy[ J]. Eye(Lond) ,2015,29(3) :376 -379.
  • 10Kawano J, Arora R. The role of adiponectin in obesity diabetes, and cardiovascular disease [ J ]. J Cardio Metab Syndr, 2009,4 ( 1 ) :44 - 49.

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二级引证文献4

中国糖尿病杂志
2007年 第2期

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