同种异体肢体(手)移植术后免疫抑制剂的应用研究

Clinical Investigation on the Application of Immunosuppressive Agents after Limb Allograft Transplantation

目的探讨同种异体肢体(手)移植术后免疫抑制剂的临床应用剂量的规律及疗效。方法通过对同种异体肢体(手)移植术后和器官移植术后免疫抑制剂应用的病例,系统性回顾分析归纳。结果4例(6肢体)同种异体肢体(手)移植术后未发生排斥反应现象,移植的6只手血循环正常,生命体征平稳。移植的6只手功能恢复较满意,没出现严重不可逆不良反应。结论在联合应用免疫抑制剂的情况下,同种异体肢体(手)移植能够存活,手部的功能可以恢复,寻找手移植术后免疫抑制剂他可莫司最佳应用剂量,以期达到最佳疗效。

Objeetive To study the rules and results of dosage treatment of clinical application of immunosuppressive agents after limb aUograft transplantation. Methods A systematic and review investigation was conducted in the cases, which all applied immunosuppressive agents after limb aUograft transplantation and organ tranplantation, The rules and treatment results of the amount of the dosage of Immunosuppressive agents in these cases were analyzed and summed up in this study. Results Rejection response after allograft limb （hand） transplantation didn＇ t appear in four cases （six limbs）. Circulation of blood in six transplanted hands is normal and vital signs are stable. Their functions recovered aatisfactorily. No serious unchangeable bad effect appeared. Condusion Under combination of application immune inhibitors, the cases of aUograft limb（hand） trausplantation can survive and can recover the functions of hand after the operation. We searched for the best application dosage of immune inhibitor tacrolimus after allograft limb and gained the best results of treatment.