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β受体基因多态性与高血压及β阻滞剂降压疗效相关性研究进展 被引量：2

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摘要 原发性高血压是与心脑血管事件发病率及死亡率增加密切相关的一种常见疾病，但目前即使在美国也仅有约1/3的患者有效地控制了其血压水平，个体对药物治疗反应的可变性和不可预见性是高血压控制率较低的重要原因之一。随着分子生物学技术的飞速发展，我们期望能从基因水平揭示高血压发病机制，同时对不同降压药物的疗效进行遗传多态性预测分析并用于指导临床用药实践。
作者 武峰 赵秀丽
机构地区 首都医科大学附属北京同仁医院
出处 《中国医药导刊》 2007年第1期27-29,共3页 Chinese Journal of Medicinal Guide
关键词 原发性高血压 Β肾上腺素能受体 基因多态性 Β阻滞剂
分类号 R544.1 [医药卫生—心血管疾病] Q753 [生物学—分子生物学]
  • 相关文献

参考文献27

  • 1Donna K.Arnett,Steven A.Claas. Pharmacogenetics of antihypertensive treatment. Drug Dev Res, 2004; 62:191-199
  • 2梁宇,赵彦艳,刘洪,时景璞.β肾上腺素能受体基因家族在中国东北高血压病高发人群中的基因型分析[J].中华医学遗传学杂志,2004,21(2):124-127. 被引量：19
  • 3Shioji K, Kokubo Y, Mannami T, et al. Association between hypertension and the alpha-adducin, beta1-adrenoreceptor and Gprotein beta3 subunit genes in the Japanese population; the Suita study. Hypertens Res, 2004, 27:31-37
  • 4Kristina Bengtsson, Olle Melander, Marju Orho-Melander, et al.Polymorphism in the β1-Adrenergic receptor gene and hypertension.Circulation, 2001; 104:187-190
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二级参考文献13

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  • 7Aynacioglu AS, Cascorbi I, Gungor K, et al. Population frequency, mutation linkage and analytical methodology for the Arg16Gly, Gln27Glu and Thr164Ile polymorphisms in the β2-adrenergic receptor among Turks. Br J Clin Pharmacol, 1999, 48∶761-764.
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共引文献18

同被引文献12

引证文献2

二级引证文献5

中国医药导刊
2007年 第1期

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