围手术期预防性使用抗菌药物合理性调查

Investigation of rationality of prophylactic antibacterial use in perioperative period

目的:调查围手术期预防性使用抗菌药物的合理性,以提高合理用药水平。方法:对我院2006年3月948例住院手术患者围手术期抗菌药物预防性使用进行回顾性调查分析。结果:948例患者在抗菌药物1841次的预防性使用中,合理1039次(56.44%);基本合理189次(10.27%);不合理613次(33.29%)。不合理用药的主要表现形式为:用药时间过长,给药时间不当,剂量过大,选药不正确,非适宜指证,给药次数过少等。结论:围手术期预防性使用抗菌药物过程中存在某些不合理用药的情况。为此,应加强贯彻实施《抗菌药物临床应用指导原则》,以避免抗菌药物的不适宜应用。

Objective： To investigate the rationality of prophylactic antibacterial use in the perioperative period in order to elevate the levels of rational drug use. Methods： Nine hundred and forth-eight inpatients receiving surgical procedure were investigated and analysed retrospectively for prophylactic antibacterial use in March, 2006. Results： Of the 1 841 times of prophylactic antibacterial use in 948 cases, 1 039 （56.44%） were rational,189 （10.27%） basically rational, and 613 （33.29%） irrational. The patterns of irrational drug use were manifested in the following forms： overlong duration of administration, inappropriate timing of administration, overdose, incorrect choice of drugs, inappropriate indication, less frequency of administration, and so on. Conclusion： There were some patterns of irrational prescribing in the prophylactic antibacterial use in the perioperative period; therefore, it is necessary to carry out ＂Guidelines on Clinical Use of Antimicrobials＂ in order to avoid the inappropriate use ofantibacterials.